A complete ingredient-by-ingredient breakdown of how Libré®'s formulas support the hormonal and physiological foundations of sexual desire.

Libré® is a physician-developed, fully transparent women's supplement brand. Its two formulas — the Daily Vitality Essential and the Life Transition Hormonal Blend — contain 16+ clinically studied ingredients, many of which directly address the root causes of low libido in women. Here is the science behind each one.

LIBRÉ®
Daily Vitality Essential

Balance · Energy · Gut Health · $129/month

Libré's foundational daily formula. Contains a comprehensive stack addressing hormonal balance, energy metabolism, stress resilience, inflammation, brain function, and gut health — all of which are direct foundations for a healthy libido. Key libido-relevant ingredients: Magnesium, Zinc, full B-Vitamin Complex, NMN, CoQ10, Omega-3 EPA+DHA, CDP-Choline, Curcumin (Longvida®), Probiotic Blend, Vitamin D3, Vitamin E, Vitamin K2, Selenium.

LIBRÉ®
Life Transition Hormonal Blend

Hot Flash Relief · Bone Health · Sleep Support · $119/month

Libré's perimenopause-targeted formula. Directly addresses the #1 cause of libido decline in women over 40: the hormonal transition. Soy Germ Extract (Aglycone isoflavones) buffers estrogen decline; sleep- support ingredients break the night sweat → poor sleep → low libido cycle; Beta-Alanine supports mood stability during hormonal shifts.

Every Libré® Ingredient That Supports Libido

Magnesium Bisglycinate
LIBRÉ · DAILY VITALITY

Regulates cortisol and the HPA stress axis — reducing the hormonal & cortisol steal' that suppresses testosterone and estrogen. Supports deep sleep quality. Reduces anxiety and muscle tension. Bisglycinate form is the most bioavailable and gentle.
Evidence: 300+ enzymatic reactions; strong cortisol-modulation data; improves sleep quality in clinical trials.

Zinc Picolinate / Bisglycinate
LIBRÉ · DAILY VITALITY

Essential for testosterone synthesis in women. Low zinc directly reduces sex hormone levels. Protects ovarian cells that produce estrogen and testosterone via antioxidant action.
Evidence: 2021 clinical study: zinc correction improved sexual function; picolinate/bisglycinate are highest- bioavailability forms.

B-Vitamin Complex (B1, B2, B6, B8, B9, B12)
LIBRÉ · DAILY VITALITY

B6 regulates hormonal activity and is essential for dopamine and serotonin synthesis — the neurotransmitters of desire. B12 supports energy and nerve function. Folate enables cellular repair. Deficiency in B- vitamins causes fatigue and depression, both of which kill libido.
Evidence: B6 EU-recognised for hormone regulation; B12 deficiency is a clinical cause of low energy and mood affecting desire.

NMN (Nicotinamide Mononucleotide)
LIBRÉ · DAILY VITALITY

Precursor to NAD+ — the cellular energy currency that declines sharply with age. Low NAD+ is associated with fatigue, hormonal decline, and reduced physical responsiveness. Restoring NAD+ supports the cellular energy foundation needed for hormonal production and sexual function.
Evidence: Emerging research confirms NMN supports energy metabolism and hormonal health in midlife women; NAD+ decline is a key mechanism of age-related libido reduction.

CoQ10 (Ubiquinol)
LIBRÉ · DAILY VITALITY

Protects ovarian cells from oxidative damage — the cells that produce estrogen and testosterone. CoQ10 supports mitochondrial energy in reproductive tissue. Particularly relevant during perimenopause when oxidative stress accelerates.
Evidence: Clinical evidence for CoQ10 in ovarian function support; especially relevant for women over 35 with declining ovarian reserve.

Omega-3 (EPA + DHA)
LIBRÉ · DAILY VITALITY

EPA supports serotonin signalling (mood, emotional wellbeing) and reduces inflammation that suppresses hormone production. DHA supports dopaminergic reward pathways involved in sexual motivation. Improves cardiovascular health and blood flow — directly relevant to arousal.
Evidence: Strong clinical evidence for mood improvement, inflammation reduction, and cardiovascular health; all documented libido pathways.

CDP-Choline
LIBRÉ · DAILY VITALITY

Supports acetylcholine — a neurotransmitter involved in arousal, sensory processing, and the brain's reward circuits. Also supports dopamine receptor sensitivity. Mental clarity and focus, which CDP-Choline promotes, are preconditions for sexual responsiveness.
Evidence: Well-researched for cognitive function and neurotransmitter support; acetylcholine's role in physical arousal is neuroscience-established.

Curcumin (Longvida®)
LIBRÉ · DAILY VITALITY

Chronic inflammation directly suppresses sex hormone production. Curcumin in its Longvida® bioavailable form crosses the blood- brain barrier and has demonstrated antidepressant effects comparable to some medications in human trials. Reduced inflammation + improved mood = improved libido.
Evidence: Meta-analyses confirm anti- inflammatory and antidepressant effects; Longvida® specifically shown to achieve therapeutic brain concentrations.

Probiotic Blend (Gastro- Resistant)
LIBRÉ · DAILY VITALITY

The gut microbiome regulates the 'estrobolome' — gut bacteria responsible for metabolising and recycling estrogen. A healthy microbiome supports optimal estrogen levels; dysbiosis accelerates estrogen excretion and worsens hormonal imbalance. 2025 research in the Journal of Sexual Medicine directly links gut microbiome diversity to sexual health and desire.
Evidence: 2025 Journal of Sexual Medicine confirms gut-sexual health axis; estrobolome science well-established for hormonal balance.

Soy Germ Extract (Aglycone Isoflavones)
LIBRÉ · HORMONAL BLEND

Aglycone isoflavones are the most bioavailable form of phytoestrogens. During perimenopause, they gently buffer the estrogen decline that causes vaginal dryness, hot flashes, and reduced desire — addressing libido at the hormonal root. Multiple RCTs confirm improvement in sexual comfort and satisfaction in perimenopausal women.
Evidence: Multiple RCTs confirm hot flash reduction, vaginal health improvement, and better sexual satisfaction; Aglycone form clinically superior in absorption.

Vitamin D3 (Cholecalciferol)
LIBRÉ · DAILY VITALITY

Vitamin D deficiency is significantly more common in women with sexual dysfunction. D3 supports testosterone production, immune function, and mood stability. Studies consistently show correction of deficiency improves hormonal balance and energy levels.
Evidence: Observational data consistently links Vitamin D deficiency to low libido and sexual dysfunction; D3 superior to D2 for bioavailability.

Selenium (Selenomethionine)
LIBRÉ · DAILY VITALITY

Essential for thyroid hormone production — and thyroid dysfunction is one of the most common, underdiagnosed causes of low libido. Optimal selenium also protects sex- hormone-producing cells from oxidative damage via antioxidant enzyme activation.
Evidence: Well-established role in thyroid function; selenomethionine is the most bioavailable organic selenium form.

Vitamin B6 (Pyridoxine)
LIBRÉ · DAILY VITALITY

Directly regulates hormonal activity and is required for the synthesis of dopamine (desire, motivation) and serotonin (mood, emotional stability). Also supports the liver's metabolism of excess estrogen, preventing estrogen dominance which can suppress testosterone.
Evidence: EU health claim recognised for hormonal regulation; clinically essential for dopamine and serotonin synthesis pathways.

Vitamin E
LIBRÉ · DAILY VITALITY

Antioxidant protection for reproductive tissue and sex- hormone-producing cells. Associated with improved vaginal tissue health and reduced dryness-related discomfort during perimenopause — a direct barrier to comfortable, desired sex.
Evidence: Evidence for antioxidant protection of reproductive tissues; associated with vaginal health improvement in perimenopausal women.

Beta-Alanine
LIBRÉ · HORMONAL BLEND

Supports mood balance and mental clarity during hormonal transition. Buffers physical and psychological stress responses, contributing to the emotional stability and stamina that are preconditions for sexual desire.
Evidence: Supports physical performance and stress buffering; relevant during hormonal transition when mood instability suppresses desire.

Vitamin K2 (MK-7)
LIBRÉ · DAILY VITALITY

Supports cardiovascular health and healthy circulation — critical for sexual arousal and genital blood flow. Poor circulation is a significant contributor to reduced arousal and sensitivity, particularly as women age.
Evidence: Strong evidence for vascular and bone health; cardiovascular function directly linked to sexual arousal response.

SHOP LIBRÉ®

Daily Vitality Essential — $129/month ($109.65 with subscription) Life Transition Hormonal Blend — $119/month ($101.15 with subscription) All ingredients are physician-developed, fully transparent, and clinically backed. Visit getlibre.co to explore each ingredient in detail.

Read more: Explore all Libré® ingredients ↗